Antimicrobial stewardship : principles and practice by This book is a joint effort led by five editors, Kerry L. LaPlante, Cheston B. Cunha, Haley J. Morrill, Louis B. Rice, and Eleftherios Mylonakis, with a team of section editors and the authors, who have brought together 38 chapters that describe the principles and practice of antimicrobial stewardship, mainly with reference to the US. There are eight sections. The first provides an overview of antibiotic stewardship, and it looks at the principles and history of, clinical perspectives on, and importance of education in antimicrobial stewardship. The second, on the principles of antibiotic resistance in antibiotic stewardship, covers the mechanisms of antibiotic resistance, the roles of selection, induction, and colonization in its emergence, and its association with antibiotic usage strategies. Section III, on the role of the microbiology laboratory, considers active surveillance, the antibiogram, selective reporting, and new diagnostics. The fourth section, on infection control, reviews the epidemiology of a number of important antimicrobial-resistant organisms and discusses the role of the hospital epidemiologist in antibiotic stewardship. Section V, on the pharmacokinetic and pharmacodynamic aspects of antibiotic dosing, deals with the principles of pharmacokinetics/pharmacodynamics, the optimal use of several classes of antibiotics, and switching from intravenous to oral dosing. The sixth section, on the role of the pharmacy department, examines the role of pharmacists, formulary management, benchmarking, and stewardship interventions and technologic support for these. Section VII deals with the measurement of outcomes of stewardship programmes, and includes discussion of the guidelines and milestones, economic aspects, adverse events, and stewardship in areas of increased resistance. The final section explores antimicrobial stewardship at different practice sites, looking at how it converges with the unique populations involved.
Chemical Kinetics: Beyond the Textbook by Processes involving randomly moving particles, which react either upon encounter or via distance-dependent reaction rates, are ubiquitous in nature. A few stray examples are recombination of ions or holes and electrons, excitation energy migration and quenching, trapping of particles by other species, coagulation, binding of ligands and proteins to specific sites, chemotaxis, catalytically-induced self-propulsion, polymerization, growth of dendrites or aggregates, or nuclei of a new phase.Several decades ago, it was recognized that the kinetic behavior in some systems with reactions and random transport is strongly affected by many factors, which were not taken into account in previous studies. These are, to name but a few, fluctuations in the spatial distributions of the reactants and fluctuations of the reactivity, some essentially many-particle phenomena, effects of anomalous diffusion, molecular crowding, as well as the internal geometry of the reaction bath. Within recent years, along with a growing interest in chemical processes ocurring in biological systems or cellular environments, numerous advances have been made and considerable knowledge has been acquired. These seminal contributions are, however, scattered among many journals and no attempt has been made so far to present a unified picture.This book presents a general overview of different contemporary facets of chemical kinetics in a variety of different environments. It includes 23 seminal works and reviews on different aspects of reaction processes in chemical, physical and biophysical systems, both theoretical and experimental.
Clinical Psychopharmacology by Clinical Psychopharmacology offers a comprehensive guide to clinical practice that explores two major aspects of the field: the clinical research that exists to guide clinical practice of psychopharmacology, and the application of that knowledge with attention to the individualized aspects of clinical practice. The text consists of 50 chapters, organized into 6 sections, focusing on disease-modifying effects, non-DSM diagnostic concepts, and essential facts about the most common drugs. This innovative book advocates a scientific and humanistic approach to practice and examines not only the benefits, but also the harms of drugs. Providing a solid foundation of knowledge and a great deal of practical information, this book is a valuable resource for practicing psychiatrists, psychiatric nurse practitioners, medical students and trainees in psychiatry, as well as pharmacists.
Diagnostic Medical Parasitology by Diagnostic Medical Parasitology covers all aspects of human medical parasitology and provides detailed, comprehensive, relevant diagnostic methods in one volume. The new edition incorporates newly recognized parasites, discusses new and improved diagnostic methods, and covers relevant regulatory requirements and has expanded sections detailing artifact material and histological diagnosis, supplemented with color images throughout the text. If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow. 
Essentials of Pharmacoeconomics by Designed as a true introduction to the subject, Essentials of Pharmacoeconomics: Health Economics and Outcomes Research, ThirdEdition includes information on fundamental topics, defines terminology, and provides examples for evaluating published research, making it perfect for any pharmacy student or practitioner new to the topic. This updated edition provides the critical foundations of knowledge for measuring costs and health-related quality-of-life (HRQoL) and evaluating the four types of studies (CMA, CEA, CUA, and CBA); it also explains Markov and Budget Impact Analysis modeling, and discusses the advantages and disadvantages of using retrospective databases and real-world data (RWD). Additionally, the text summarizes the use of pharmacoeconomic evaluations by decision makers outside of the United States and the extent to which pharmacoeconomic data are used to make decisions in the United States, includes barriers to its use, and discusses future issues. All of this information is designed to ensure preparedness to improve clinical and humanistic outcomes based on available resources. Updated Composite research articles throughout the text demonstrate how to evaluate the positive and negative aspects found in a mix of published research articles. New! Full examples of decision analysis and Markov analysis are available on thePoint. Key terms are bolded throughout the textbook, and definitions of these terms are summarized in a glossary. Pharmacoeconomics research uses terminology derived from other disciplines, such as economics, that might not be familiar to all readers. Equations readers will need to know are explained using multiple example calculations. Questions/Exercises appear at the end of most chapters so that readers can assess their understanding of key concepts. Answers are included at the back of the textbook. References and Suggested Readings at the end of each chapter provide resources available to the reader for further study on the chapter topic. eBook available. Fast, smart, and convenient, today's eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and much more.
The Gates of Europe by A New York Times bestseller, this definitive history of Ukraine is "an exemplary account of Europe's least-known large country" (Wall Street Journal). As Ukraine is embroiled in an ongoing struggle with Russia to preserve its territorial integrity and political independence, celebrated historian Serhii Plokhy explains that today's crisis is a case of history repeating itself: the Ukrainian conflict is only the latest in a long history of turmoil over Ukraine's sovereignty. Situated between Central Europe, Russia, and the Middle East, Ukraine has been shaped by empires that exploited the nation as a strategic gateway between East and West--from the Romans and Ottomans to the Third Reich and the Soviet Union. In The Gates of Europe, Plokhy examines Ukraine's search for its identity through the lives of major Ukrainian historical figures, from its heroes to its conquerors. This revised edition includes new material that brings this definitive history up to the present. As Ukraine once again finds itself at the center of global attention, Plokhy brings its history to vivid life as he connects the nation's past with its present and future.
Handbook of pharmaceutical excipients by 
Microbial Metabolism and Disease by Microbiome Metabolic Pathways and Disease provides insight into the interaction of microbial metabolic pathways in the human body and the impact these can have on a variety of diseases. By analyzing these pathways the book seeks to investigate how these metabolic processes can be targeted and manipulated in order to treat various disorders and diseases. Topics covered in the book include microbial shikimate pathways, protein biosynthesis, tryptophan metabolites, microbiome metabolic engineering, fecal microbiota transplantation, and virulence factors. Additionally, a variety of conditions are covered, such as disorders associated with metabolic syndromes, serotonin syndromes, Alzheimer's disease, and Covid-19, providing a detailed overview of how metabolic pathways of microbiome can impact health and disease in the human body. Explores microbial metabolic pathways in the human body and implications for disease Investigates specific steps involved in metabolic reactions in the human microbiome, including shikimate pathways and tryptophan pathways Considers a variety of diseases and disorders, such as Alzheimer's disease, metabolic syndromes, Crohn's disease and Covid-19 Includes analysis of various amino acids and enzymes in microbial and human cells and how these can impact health
Pharmacoepidemiology by This classic, field-defining textbook, now in its sixth edition, provides the most comprehensive guidance available for anyone needing up-to-date information in pharmacoepidemiology. This edition has been fully revised and updated throughout and continues to provide a rounded view on all perspectives from academia, industry and regulatory bodies, addressing data sources, applications and methodologies with great clarity.
The Price of Health by From "pharma bros" to everday household budgets, just how did the pharmaceutical industry betray its own history--and how can it return to its tradition of care? It's an unfortunate and life-threatening fact: one in five Americans has skipped vital prescriptions simply because of the cost. These choices are being made even though we have reached a point in the conveyance of medical options where cancers can be cured and sight restored for those blinded by rare genetic disorders. How, in this time of such advancements, did we reach a point, where people cannot afford the very things that could save their lives? As the COVID-19 global pandemic has pointed out, we need the leadership of scientists, researchers, public health officials and lawmakers alike to guide us through not only in times of a global health crisis, but also during far more mundane times. For the first time in decades, people from all walks of life face the same need for medicine. It is time to discuss the tough questions about drug pricing in an open, honest and, hopefully, transparent manner. But first we must understand how we, as a society, got here. Medicines are arguably the most highly regulated--and cost-inflated--products in the United States. The discovery, development, manufacturing and distribution of medicines is carried out by an ever more complex and crowded set of industries, each playing a part in a larger "pharmaceutical enterprise" seeking to maximize profits. But this was not always the case. The Price of Health is the reveals the story of how the pharmaceutical enterprise took shape and led to the present crisis. The reputation of the pharmaceutical industry is suffering from self-inflicted wounds and its continued viability, indeed survival, is increasingly questioned. Yet the drug makers do not shoulder all the blame or responsibility for the current price crisis. Deeply researched, The Price of Health gives us hope as to how we can still right the ship, even amidst the roiling storm of a global pandemic. How have medicines have been made and distributed to consumers throughout the years? What sea of changes that have contributed to rising costs? Some individuals, actions, and systems will be familiar, others may surprise. Yet the combined implications of these actions for will be surprising and at times shocking to both industry professionals and average Americans alike. Like so much else in human history, the history of the pharmaceutical enterprise is populated mostly by well-intended and even noble individuals and organizations. Each contributed to the formation or maintenance of structures meant to improve the quality and quantity of life through the development and distribution of medicines. And yet systems originally created to do good have often been subverted in ways contrary to the motivations of their creators. Only by understanding this disconnect can we better tackle the underlying problems of the industry head on, preventing foreseeable, and thus avoidable, medical calamities to come.
Renal Medicine and Clinical Pharmacy by This first volume of an exciting new book series offers a comprehensive and logically organized introduction to clinical pharmacy as applied to renal medicine. The volume opens with a review of renal pharmacokinetics: absorption; distribution; metabolism; and elimination, as well as drug dosing in renal impairment, and important knowledge specific to aging and renal impairment. Acute kidney injury receives extensive attention, including pre-renal, intra-renal, and post-renal injuries. The book also outlines the role of clinical pharmacy in chronic kidney disease and end stage renal failure. Additional chapters provide detailed information on the methods and pharmacokinetics of renal dialysis, and the epidemiology and management of drug-induced nephrotoxicity. The Advanced Clinical Pharmacy series provides a review of core pharmaceutical concepts, a foundation for optimizing pharmacotherapy, and an introduction to advanced clinical practice. The editors and contributors are international experts who distill the core knowledge of each specialty. The books offer real-world insights to benefit both new practitioners, and experienced pharmacists exploring new areas of clinical pharmacy
That High Design of Purest Gold by "This book is a history of medicines and the commercial actors that make and sell them, covering the 140 years since the modern pharmaceutical industry came into being. It is written in a lively and accessible way, aiming at a general audience that combines historical narrative with fascinating case studies on drug discovery and commercialization, from the rat poison that became warfarin, to a cardiovascular treatment that was turned into Viagra. In a non-partisan way it also examines some of the less noble manifestations of corporate behavior, concluding with an agenda for reform. It is hard to think of anything nobler than to bring to the world a medicine that saves lives. And over 140 years of history, the pharmaceutical industry has produced a range of remarkable products, albeit typically with external scientific and financial support. Making medicines is a very big and profit-driven business, and the industry does not always make the right products for the right people, or at the right prices. The industry wields immense power over lives and economies. How has it risen to this position of dominance? Are the interests of the industry and the public in balance? What should we admire about the industry? What should we criticise and seek to change? The importance of this book lies in the fact that we are all stakeholders in this industry whether or not we own shares, so we all need answers to these questions"--